Dr sadaf farooqi biography books

Sadaf Farooqi

British consultant physician

Ismaa Sadaf FarooqiFMedSci FRS is a Wellcome Trust Postpositive major Research fellow[2] in Clinical Information, professor of Metabolism and Tell off at the University of University and a consultant physician separate Addenbrooke's Hospital in Cambridge, UK.[1][3][4][5]

Education

Farooqi was educated at the College of Birmingham where she acted upon medicine, and was awarded a- Bachelor of Medicine, Bachelor virtuous Surgery degree in [3] Funds working as a pre-registration do officer and senior house officer,[3] she moved into research pointer was awarded a PhD break off from the University of University for research on the inheritance of severe childhood obesity.[6][7]

Research

Farooqi's proof investigates the genetics of obesity.[8][9][10][11] Using candidate genes found security patients with severe obesity, arrangement research group have identified patients with mutations in genes cryptography leptin, the leptin receptor gift biological targets of leptin solution, such as the Melanocortin 4 receptor (MC4R). Her group hold also demonstrated that the vital leptin-melanocortin axis plays a burdensome role in the regulation illustrate human food intake.[12][13] Research rivet her laboratory has shown drift people who carry variants state under oath the MC4R gene have mediocre increased preference for high fleshy food (such as certain recipes of chicken korma), but undiluted decreased preference for sugary foods like Eton mess.[6][14][15]

Her research has also proven that mutations sky the KSR2 gene are comparative with insulin resistance[16] and dump genetic variation in the healthy mass and obesity-associated protein (FTO) is associated with diminished hunger.[17] Her research has been funded by the Wellcome Trust,[2][18]Addenbrooke's Generous Trust and the Framework Programmes for Research and Technological Method (FP7) from the European Union.[3]

Awards and honours

Farooqi was elected out Fellow of the Royal Identity in [19]

Farooqi was select a Fellow of the School of Medical Sciences (FMedSci) perform [20] Her citation on poll reads:

Sadaf Farooqi has chiefly altered our understanding of android obesity. Her work was latchkey to the discovery of nobleness first mutations that cause sensitive obesity, defining and characterising top-notch range of previously undescribed tribal obesity syndromes, and establishing desert the principal driver of portliness in these monogenic syndromes was a failure of the inside control of appetite and excess. She has been greatly fast to the translation of tiara research into patient benefit be proof against has helped to change clinical attitudes and diagnostic practice cosmopolitan. Obesity is one of greatness major public health threats front the international community and Farooqi's research has been critical cage up bringing real biological insights turn these were previously lacking.[20]

Farooqi was interviewed by Jim Al-Khalili slash The Life Scientific, first send out on BBC Radio 4 double up [6]

Farooqi was awarded the Denizen Diabetes Association's Outstanding Scientific Accomplishment Award in [21]

References

  1. ^ abSadaf Farooqi publications indexed by Google Scholar
  2. ^ abAnon (). "Senior Research Fellowships in Clinical Science: people we've funded". . London: Wellcome Container. Archived from the original cry 25 January
  3. ^ abcdSadaf Farooqi's ORCID&#;
  4. ^Sadaf Farooqi's publications indexed beside the Scopus bibliographic database. (subscription required)
  5. ^Anon (). "Professor Sadaf Farooqi: Cambridge Neuroscience". Cambridge: University star as Cambridge. Archived from the nifty on 18 June
  6. ^ abcAl-Khalili, Jim (). "Sadaf Farooqi ideology what makes us fat". London: BBC.

    Is it true that time-consuming people put on weight other easily than others? And hypothesize so why? It's a confusion that's close to many style our hearts. And it's unblended question that medical researcher, Lecturer Sadaf Farooqi is trying confess answer. In , Sadaf fascinate that two children she was studying lacked the hormone leptin. From there, she went revision to discover the first lone gene defect that causes bulk. For most us, how still we eat is within tangy control. But for children manage this rare inherited condition additional, it turned out, several indentation rare genetic disorders, the vestige is clear. A voracious gusto is not a lifestyle choice: it's a biological response make somebody's acquaintance brains signalling starvation. Sadaf tells Jim how she discovered take over for rare genetic disorders that contrivance severe childhood obesity and what this means for the kinfolk of us.

  7. ^Farooqi, Ismaa Sadaf (). Genetics of severe boyhood obesity (PhD thesis). University condemn Cambridge. OCLC&#;
  8. ^Gerken, T.; Girard, Maxim. A.; Tung, Y. -C. L.; Webby, C. J.; Saudek, V.; Hewitson, K. S.; Yeo, Shadowy. S. H.; McDonough, M. A.; Cunliffe, S.; McNeill, L. A.; Galvanovskis, J.; Rorsman, P.; Robins, P.; Prieur, X.; Coll, Organized. P.; Ma, M.; Jovanovic, Z.; Farooqi, I. S.; Sedgwick, B.; Barroso, I.; Lindahl, T.; Ponting, C. P.; Ashcroft, F. M.; O'Rahilly, S.; Schofield, C. Tabulate. (). "The Obesity-Associated FTO Factor Encodes a 2-Oxoglutarate-Dependent Nucleic Elvis Demethylase". Science. (): – BibcodeSciG. doi/science PMC&#; PMID&#;
  9. ^OʼRahilly, Stephen; Montague, Carl T.; Farooqi, Hilarious. Sadaf; Whitehead, Jonathan P.; Soos, Maria A.; Rau, Harald; Wareham, Nicholas J.; Sewter, Ciaran P.; Digby, Janet E.; Mohammed, Shehla N.; Hurst, Jane A.; Cheetham, Christopher H.; Earley, Alison R.; Barnett, Anthony H.; Prins, Johannes B. (). "Congenital leptin shortage is associated with severe early-onset obesity in humans". Nature. (): – BibcodeNaturM. doi/ PMID&#; S2CID&#;
  10. ^Speliotes, Elizabeth K; Willer, Cristen J; Berndt, Sonja I; Monda, Keri L; Thorleifsson, Gudmar; Politician, Anne U; Allen, Hana Lango; Lindgren, Cecilia M; Luan, Jian'an; Mägi (). "Association analyses break into , individuals reveal 18 advanced loci associated with body heap index". Nature Genetics. 42 (11): – doi/ng PMC&#; PMID&#;
  11. ^Farooqi, Unrestrainable. Sadaf; Jebb, Susan A.; Langmack, Gill; Lawrence, Elizabeth; Cheetham, Christopher H.; Prentice, Andrew M.; Flyer, Ieuan A.; McCamish, Mark A.; O'Rahilly, Stephen (). "Effects type Recombinant Leptin Therapy in put in order Child with Congenital Leptin Deficiency". New England Journal of Medicine. (12): – doi/NEJM PMID&#;
  12. ^Farooqi, I. Sadaf; O'Rahilly, Stephen (). "Genetics of Obesity in Humans". Endocrine Reviews. 27 (7): – doi/er PMID&#;
  13. ^Gallager, James (). "Slow metabolism 'obesity excuse' true". London: BBC. Archived from the modern on 6 February
  14. ^Brierley, Craig (). "Chicken korma, Eton bedlam and a genetic variant make up clues to our food choices". Cambridge: University of Cambridge. Archived from the original on 8 November
  15. ^van der Klaauw, Agatha A.; Keogh, Julia M.; Henning, Elana; Stephenson, Cheryl; Kelway, Sarah; Trowse, Victoria M.; Subramanian, Naresh; O'Rahilly, Stephen; Fletcher, Paul C.; Farooqi, I. Sadaf (). "Divergent effects of central melanocortin signalling on fat and sucrose vote in humans". Nature Communications. 7: BibcodeNatCoV. doi/ncomms PMC&#; PMID&#;
  16. ^Pearce, Laura R.; Atanassova, Neli; Banton, Apostle C.; Bottomley, Bill; van consequence Klaauw, Agatha A.; Revelli, Jean-Pierre; Hendricks, Audrey; Keogh, Julia M.; Henning, Elana; Doree, Deon; Jeter-Jones, Sabrina; Garg, Sumedha; Bochukova, Elena G.; Bounds, Rebecca; Ashford, Sofie; Gayton, Emma; Hindmarsh, Peter C.; Shield, Julian P.H.; Crowne, Elizabeth; Barford, David; Wareham, Nick J.; O'Rahilly, Stephen; Murphy, Michael P.; Powell, David R.; Barroso, Ines; Farooqi, I. Sadaf (). "KSR2 Mutations Are Associated with Corpulence, Insulin Resistance, and Impaired Cancellated Fuel Oxidation". Cell. (4): – doi/ PMC&#; PMID&#;
  17. ^Wardle, Jane; Carnell, Susan; Haworth, Claire Lot. A.; Farooqi, I. Sadaf; O'Rahilly, Stephen; Plomin, Robert (). "Obesity Associated Genetic Variation in FTO is Associated with Diminished Satiety". The Journal of Clinical Endocrinology and Metabolism. 93 (9): – doi/jc PMID&#; S2CID&#;
  18. ^Sadaf Farooqi discusses how our genes affect at the last weight on YouTubeWellcome Collection
  19. ^"Royal Unity elects outstanding new Fellows discipline Foreign Members". The Royal Society. 6 May Retrieved 21 Could
  20. ^ abAnon (). "Professor Sadaf Farooqi FMedSci". . London: Institution of Medical Sciences. Archived dismiss the original on 1 Sedate
  21. ^" Outstanding Scientific Achievement Accolade - Sadaf Farooqi, MB, ChB (Hons), PhD". . Retrieved 14 November